Generic Name: phendimetrazine (fen di MEH tra zeen)
Brand Names: Adipost, Bontril PDM, Bontril Slow Release, Melfiat
What is Prelu-2 (phendimetrazine)?
Phendimetrazine is similar to an amphetamine. Phendimetrazine stimulates the central nervous system (nerves and brain), which increases your heart rate and blood pressure and decreases your appetite.
Phendimetrazine is used as a short-term supplement to diet and exercise in the treatment of obesity.
Phendimetrazine may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Prelu-2 (phendimetrazine)?
Phendimetrazine may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. Phendimetrazine may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it. Do not stop using phendimetrazine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using phendimetrazine. Do not crush, chew, break, or open the extended-release capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.
What should I discuss with my healthcare provider before taking Prelu-2 (phendimetrazine)?
Do not use phendimetrazine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. You should not use this medication if you are allergic to phendimetrazine, or if you have:
coronary artery disease (hardening of the arteries);
heart disease;
severe or uncontrolled high blood pressure;
heart murmur or heart valve disorder;
pulmonary arterial hypertension (PAH);
overactive thyroid;
glaucoma;
severe agitation or nervousness;
if you have a history of drug or alcohol abuse; or
if you are allergic to other diet pills, amphetamines, stimulants, or cold medications.
To make sure you can safely take phendimetrazine, tell your doctor if you have any of these other conditions:
high blood pressure;
diabetes;
an anxiety disorder;
epilepsy or seizure disorder; or
if you have used other diet pills in the past year (prescription, over-the-counter, or herbal products).
It is not known whether phendimetrazine will harm an unborn baby. Do not take phendimetrazine without first talking to your doctor if you are pregnant. It is also not known whether phendimetrazine passes into breast milk. Do not take phendimetrazine without first talking to your doctor if you are breast-feeding a baby.
How should I take Prelu-2 (phendimetrazine)?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Phendimetrazine should be taken only for a short time, such as a few weeks.
Phendimetrazine is usually taken once daily. Follow your doctor's instructions.
Take phendimetrazine on an empty stomach, 30 to 60 minutes before your morning meal. Do not crush, chew, break, or open the extended-release capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time. You should lose at least 4 pounds during the first 4 weeks of taking phendimetrazine and eating a low calorie diet. Tell your doctor if you do not lose at least 4 pounds after taking the medication for 4 weeks. Do not stop using phendimetrazine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using phendimetrazine. Never take more of this medication than is prescribed for you. Too much phendimetrazine could be very dangerous to your health. Talk with your doctor if you have increased hunger or if you otherwise think the medication is not working properly. Taking more of this medication will not make it more effective and can cause serious, life-threatening side effects. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
A dose taken too late in the day will cause insomnia.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of phendimetrazine can be fatal.
Overdose symptoms of a phendimetrazine overdose include nausea, vomiting, diarrhea, stomach cramps, confusion, panic, hallucinations, extreme restlessness, feeling tired or depressed, ringing in your ears, chest pain, slow heart rate, weak pulse, fainting, seizure, or slow breathing (breathing may stop).
What should I avoid while taking Prelu-2 (phendimetrazine)?
Phendimetrazine may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.
Prelu-2 (phendimetrazine) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using phendimetrazine and call your doctor at once if you have a serious side effect such as:
feeling short of breath, even with mild exertion;
chest pain, feeling like you might pass out;
swelling in your ankles or feet;
pounding heartbeats or fluttering in your chest;
confusion or irritability, unusual thoughts or behavior;
feelings of extreme happiness or sadness; or
dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).
Less serious side effects may include:
feeling restless or hyperactive;
headache, dizziness, tremors;
sleep problems (insomnia);
flushing (warmth, redness, or tingly feeling);
dry mouth;
diarrhea or constipation, upset stomach; or
increased or decreased interest in sex, impotence.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Prelu-2 (phendimetrazine)?
Tell your doctor about all other medicines you use, especially:
insulin; or
any other diet pills.
This list is not complete and other drugs may interact with phendimetrazine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
More Prelu-2 resources
- Prelu-2 Side Effects (in more detail)
- Prelu-2 Use in Pregnancy & Breastfeeding
- Drug Images
- Prelu-2 Drug Interactions
- Prelu-2 Support Group
- 0 Reviews for Prelu-2 - Add your own review/rating
- Prelu-2 Advanced Consumer (Micromedex) - Includes Dosage Information
- Phendimetrazine Prescribing Information (FDA)
- Bontril PDM MedFacts Consumer Leaflet (Wolters Kluwer)
- Phendimetrazine Tartrate Monograph (AHFS DI)
Compare Prelu-2 with other medications
- Obesity
Where can I get more information?
- Your pharmacist can provide more information about phendimetrazine.
See also: Prelu-2 side effects (in more detail)
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